In Situ Detection of Apoptosis

Apoptosis is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay.Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. ​Various methods are available for detection of apoptotic cells in situ. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase 3 IHC are common methods for apoptotic cell detection in situ.

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