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Services for Covid-19 Research

About COVID-19

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. The outbreak was declared a Public Health Emergency of International Concern on 30 January 2020. Up to now, COVID-19 has been recognized in the world, with millions of  laboratory-confirmed cases and more than several 100 thousand deaths. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. As a novel disease, many mysteries of COVID-19 are still uncovered. VitroVivo will contribute our expertise in molecular pathology and offers SARS-CoV-2 ISH and related gene IHC services to accelerate COVID-19 investigation.

Histopathology and Molecular Pathology Services for COVID-19 Research 

1. In Situ Detection of Viral RNA Markers

Services Provided by VitroVivo Application
 SARS-CoV-2 In Situ Hybridization (ISH)Detect specific RNA for SARS-CoV-2, S gene encoding the spike protein in situ.
 nCoV-2019-S Sense In Situ hybridization (ISH)Detect specific RNA for SARS-CoV-2, the “sense” probe targets the antisense strand of the S gen in situ.

2.  In Situ Detection of SARS-CoV-2 receptor: ACE2

Services Provided by VitroVivo  Application
Angiotensin Converting Enzyme-2 (ACE2) IHC or ISHDetect localization and expression level of SARS-CoV-2 receptor ACE2 in tissue in situ.

Reference: Shang, J. . et al. Structural basis of receptor recognition by SARS-CoV-2. Nature https://doi.org/10.1038/s41586-020-2179-y (2020).

3. In Situ Detection of Cytokine Storm Markers

Services Provided by VitroVivo Application
ISH or IHC for IL-1B, IL-6, IL2,IL10, TNFα,IFNγ, IL8,IL-12, IL-4Detect the expression of cytokine storm markers in situ.

4. In Situ Detection of Lung Tissue/ARDS Markers

Services Provided by VitroVivo Application
IHC or ISH for AQP5, SFTPB, RAGE (AGER), SP-D (SFTPD), KL-6 (MUC1), CC16 (SCGB1A1)Detect the expression of cytokine storm markers in situ.

5. Immunohistochemical Identification of Immune and Inflammatory cells

Services Provided by VitroVivo Application (human)
CD3 IHCT Cell marker
CD4 IHCHelper T Cell (Th) marker
CD8 IHCCytotoxic T Cell marker
FOXP3 IHCRegulatory T cell (Treg) marker
CD68 IHCMacrophage marker
CD80, CD86, or iNOS IHCpro-inflammatory (M1-like) Macrophage marker
CD163 or CD206 IHCanti-inflammatory (M2-like) Macrophage marker
CD56/ CD3 IHC (IF)NKT Cell (CD56+/ CD3+) and NK Cell  (CD56+and CD3-) marker
CD19 IHCB Cell marker
CD138 IHCPlasma Cell marker
CD11b IHCMyeloid Cell marker
CD45 IHCLeukocyte marker

 

Fig.   Molecular immune pathogenesis and diagnosis of COVID-19

From: X. Li et al., Molecular immune pathogenesis and diagnosis of COVID-19, Journal of Pharmaceutical Analysis, https://doi.org/10.1016/j.jpha.2020.03.001

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Rat Tissue Arrays

Need more information, quote or place an order?  Please email to: info@vitrovivo.com

SKU#

DESCRIPTION

 CASE

CORE

PRICE ($)

RAT301Rat brain tissue array, 30 cases/30 cores3030149.5
RAT301aRat brain tissue array, 30 cases/30 cores, replacing RAT3013030149.5
RAT901aRat multiple organs normal tissue array, 36 cases/90 cores, replacing RAT9013690292.5
BR01015Rat multiple organs normal tissue array, 49 rats/160 cores49160331.5
TR171Rat normal brain tissue array, 6 cases/24 cores62471.5
TR071aRat normal kidney tissue array, 6 cases/24 cores, replacing TR07162452
TR071bRat normal kidney tissue array, 6 cases/24 cores, replacing TR071a62445.5
TR031Rat normal liver test tissue array, 6 cases/24 cores62452
TR041Rat normal lung test tissue array, 6 cases/24 cores62452
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Mouse Tissue Arrays

Need more information, quote or place an order?  Please email to: info@vitrovivo.com

SKU#

DESCRIPTION

CASE

CORE

PRICE ($)

MO17011a

MO1601a

Mouse brain tissue array, 100 cases/ 100 cores, replacing MO17011

Mouse multiple organ normal tissue array, 160 cases/160 cores, replacing MO1601

100

160

100

160

182.00

292.50

 

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Other Organ Tissue Arrays

Please send your request for detailed information and quote to: info@vitrovivo.com

SKU#

DESCRIPTION

CASE

CORE

PRICE ($)

ST8011Cardia disease spectrum (cardia cancer progression) with normal tissue array, including Her-2 result, pathology grade, TNM and clinical stage, 80 cases/80 cores8080331.50
MAC801aAdenoid cystic carcinoma tissue array, 40 cases/80 cores, replacing MAC8014080292.50
T411Appendix cancer with appendix tissue test array, including pathology grade, TNM and clinical stage, 6 cases/24 cores62471.50
VA1001Vermiform appendix disease spectrum (vermiform appendix cancer progression) tissue array, including pathology grade, 50 cases/100 cores50100331.50
MC809aBlastoma tissue array with normal tissue, including pathology grade, TNM and clinical stage, 80 cases/80 cores, replacing MC8098080448.50
T001aEmbryonal tumor test tissue array, with normal tissue as control, including TNM and clinical stage, 6 cases/24 cores, replacing T00162471.50
MC807Embryonal carcinoma tissue array with normal tissue, including TNM and clinical stage, 40 cases/80 cores4080448.50
MY801Mesentery primarily malignant tumor tissue array, 40 cases/80 cores4080513.50
SS1501Multiple synovial disease tissue array, including TNM and clinical stage, 150 cases/ 150 cores150150591.50
BC49001Parasite infection tissue array with matched tumor as control, including pathology grade, TNM and clinical stage, 20 cases/80cores2080591.50

TMA Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH)

Notes:

1) TMA slides were sectioned and stored at 4°C and may not be fresh cut, but still suitable for IHC. Please request fresh cut if experiment involves phospho-specific antibodies, RNA studies, FISH or ISH, etc. A minimum of 3 slides per TMA must be purchased to cover the cost of trimming for fresh sectioning.
2) Most TMA slides were not coated with an extra layer of paraffin (tissue cores can be easily seen on the glass). To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60°C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.

TNM Grading

T – Primary tumor
      Tx – Primary tumor cannot be assessed
      T0 – No evidence of primary tumor
      Tis – Carcinoma in situ; intraepithelial or invasion of lamina propria
      T1 – Tumor invades submucosa
      T2 – Tumor invades muscularis propria
      T3 – Tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues.
      T4 – Tumor directly invades other organs or structures and/or perforate visceral peritoneum

N – Regional lymph nodes
     Nx – Regional lymph nodes cannot be assessed
     N0 – No regional lymph node metastasis
     N1 – Metastasis in 1 to 3 regional lymph nodes
     N2 – Metastasis in 4 or more regional lymph nodes

M – Distant metastasis
     Mx – Distant metastasis cannot be assessed
     M0 – No distant metastasis
     M1 – Distant metastasis

Stage of Cancer

  • Stage 0 means there’s no cancer, only abnormal cells with the potential to become cancer. This is also called carcinoma in situ.
  • Stage I means the cancer is small and only in one area. This is also called early-stage cancer.
  • Stage II and III mean the cancer is larger and has grown into nearby tissues or lymph nodes.
  • Stage IV means the cancer has spread to other parts of your body. It’s also called advanced or metastatic cancer.
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Mesothelioma Tissue Arrays

Please send your request for detailed information and quote to: info@vitrovivo.com

SKU#

DESCRIPTIO

CASE

CORE

 PRICE ($)

MS481cMesothelioma tissue array with normal tissue, including TNM, pathology grade and clinical stage, 24 cases/48 cores, replacing MS481b2448383.50
MS801aMesothelioma with mesothelium tissue array, including TNM and clinical stage, 40 cases/80 cores, replacing MS8014080448.50
T392aMalignant mesothelioma with pleura tissue test tissue array, including TNM and clinical stage, 6 cases/24 cores, replacing T39262471.50

TMA Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH)

Notes:

1) TMA slides were sectioned and stored at 4°C and may not be fresh cut, but still suitable for IHC. Please request fresh cut if experiment involves phospho-specific antibodies, RNA studies, FISH or ISH, etc. A minimum of 3 slides per TMA must be purchased to cover the cost of trimming for fresh sectioning.
2) Most TMA slides were not coated with an extra layer of paraffin (tissue cores can be easily seen on the glass). To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60°C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.

TNM Grading

T – Primary tumor
      Tx – Primary tumor cannot be assessed
      T0 – No evidence of primary tumor
      Tis – Carcinoma in situ; intraepithelial or invasion of lamina propria
      T1 – Tumor invades submucosa
      T2 – Tumor invades muscularis propria
      T3 – Tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues.
      T4 – Tumor directly invades other organs or structures and/or perforate visceral peritoneum

N – Regional lymph nodes
     Nx – Regional lymph nodes cannot be assessed
     N0 – No regional lymph node metastasis
     N1 – Metastasis in 1 to 3 regional lymph nodes
     N2 – Metastasis in 4 or more regional lymph nodes

M – Distant metastasis
     Mx – Distant metastasis cannot be assessed
     M0 – No distant metastasis
     M1 – Distant metastasis

Stage of Cancer

  • Stage 0 means there’s no cancer, only abnormal cells with the potential to become cancer. This is also called carcinoma in situ.
  • Stage I means the cancer is small and only in one area. This is also called early-stage cancer.
  • Stage II and III mean the cancer is larger and has grown into nearby tissues or lymph nodes.
  • Stage IV means the cancer has spread to other parts of your body. It’s also called advanced or metastatic cancer.
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Stomach Tissue Arrays

Please send your request for detailed information and quote to: info@vitrovivo.com

SKU#

DESCRIPTION

CASE

CORE

PRICE ($)

BN01013aNormal gastric tissue array (multi-sites), 72 cases/72 cores, replacing BN010137272214.5
DST-963Advanced stage of stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage (AJCC 7th edition), 95 cases/95 cores9595331.5
ST963Advanced stage of stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage (AJCC 7th edition), 95 cases/95 cores9595331.5
DST8014bDifferent stages of stomach cancer and normal tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores, replacing DST-8014a8080331.5
DST8014cDifferent stages of stomach cancer and normal tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores, replacing DST8014b8080331.5
ST8016Different stages of stomach cancer tissue array, with metastasis tissue,including pathology grade, TNM and clinical stage, 80 cases/80 cores8080292.5
ST601Gastric fundus cancer with normal tissue array, including pathology grade, TNM and clinical stage, 30 cases/ 60 cores3060240.5
ST8017Gastric mucosa intestinal metaplasia tissue array, 80 cases/80 core4080331.5
ST8017aGastric mucosa intestinal metaplasia tissue array, 80 cases/80 cores, replacing ST80174080331.5
CA941Gastroesophageal junction (GEJ) cancer tissue array, including pathology grade, TNM and clinical stage, 94 cases/94 cores9494331.5
GIST801aGastrointestinal stromal tumors (GISTs) tissue array, 80 cases/80 cores replacing GIST8018080331.5
GI962Gastrointestinal tract interstitialoma tissue array, including TNM and clinical stage and IHC markers (CD117) results, 96 cases/96 cores9696331.5
ST208High density stomach cancer and normal tissue array, including pathology grade, TNM and clinicall satge, 69 cases/207 cores70208591.5
ST8013aMultiple organs metastatic adenocarcinoma from stomach tissue array,40 cases/80 cores,replacing ST80134080331.5
ST2084Multiple parts of gastric cancer with matched cancer adjacent gastric tissue array, with cardia, gastric fundus, gastric body, gastric antrum and pylorus, including pathology grade, TNM and clinical stage, 104 cases/ 208 cores, replaced by ST2084a104208591.5
ST2084aMulti-site gastric cancer with matched adjacnet normal tissue or cancer adjacent tissue array, including pathology grade, TNM and clinical stage, 96 cases/192 cores, replacing ST208496192591.5
STN241Normal stomach tissue array, 24 cases/24 cores2424214.5
ST723Poorly differentiated stomach adenocarcinoma with adjacent normal tissue array, including pathology grade, TNM and clinical stage, 23 cases/72 cores, replacing BS010422472292.5
SLC601Stomach cancer and lung cancer tissue array, including pathology grade, TNM and clinical satge, 60 cases/60 cores6060331.5
ST1401bStomach cancer and stomach tissue array, including pathology grade, TNM and clinical stage, 140 cases/140 cores, replacing ST1401a140140578.5
ST482bStomach cancer and stomach tissues array, including pathology diagnosis, TNM and clinical stage, 24 cases/48 core, replacing ST482a2448214.5
ST1451Stomach cancer survival tissue array, including pathology grade, TNM and clinical stage, 71 cases/145 cores711451228.5
T014Stomach cancer test tissue array (4x (2×3)array), including TNM, clinical stage and pathology grade, 6 cases/24 cores62445.5
ST1003aStomach cancer tissue array for antibody screening, including pathology grade, TNM and clinical stage, 50 cases/100 cores, replacing ST100350100331.5
T013aStomach cancer tissue array with normal stomach tissue, including TNM, clinical stage and pathology grade, 6 cases/24 cores, replacing T01362445.5
DST8020Stomach cancer tissue array with normal tissue, including pathology grade, TNM and clinical stage, 80 cases/80 cores8080331.5
ST8012Stomach cancer tissue array with stomach tissues, including pathology grade, TNM and clinical satge, 40 cases/80 cores4080331.5
BC01014Stomach cancer tissue array, including pathology grade, TNM and clinical stage, 71 cases/72 cores7172292.5
ST1401Stomach cancer tissue array, including TNM and pathology grade, IHC marker Her-2 results, 140 cases/140 cores140140578.5
ST483dStomach cancer tissue array, including TNM, clinical stage and pathology grade, 48 cases/48 cores, replaced by ST483c4848240.5
ST483f(ST483e)Stomach cancer tissue array, including TNM, clinical stage and pathology grade, 48 cases/48 cores, replaced by ST483e4848240.5
ST484bStomach cancer tissue array, including TNM, clinical stage and pathology grade, 48 cases/48 cores, replacing ST484a4848240.5
ST484cStomach cancer tissue array, including TNM, clinical stage and pathology grade, 48 cases/48 cores, replacing ST484b4848273
ST1005Stomach cancer tissue array, with metastatic cancer, including pathology grade, TNM and clinical stage, 50 cases/100 cores50100331.5
DST-244bStomach cancer with matched adjacent normal stomach tissue array, including pathology grade, TNM and clinical stage, 6 cases/24cores, replacing ST244a62484.5
ST242Stomach cancer with matched adjacent normal tissue array, including pathology grade, TNM and clinical stage, 10 cases/24 cores102471.5
DST-242bStomach cancer with matched adjacent normal tissue array, including pathology grade, TNM and clinical stage, 10 cases/24 cores, replacing DST242a102471.5
DST-242aStomach cancer with matched adjacent normal tissue array, including pathology grade, TNM and clinical stage, 10 cases/24 cores, replacing ST242102471.5
ST801aStomach cancer with matched adjacent normal tissue array, including pathology grade, TNM and clinical stage, 40 cases/80 cores, replacing ST8014080292.5
ST485Stomach cancer with matched cancer adjacent tissue array, including pathology grade, TNM and clinical stage, 16 cases/48 cores1648292.5
ST810cStomach cancer with matched lymph node metastatic carcinoma tissue array, including pathology grade, TNM and clinical stage, 40cases/ 80 cores, replacing ST810b4080292.5
DST-461Stomach cancer with matched stomach tissue array (2010 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 23 cases/46 cores2346214.5
ST961Stomach cancer with stomach tissue array, including pathology grade, TNM and clinical satge, 48 cases/96 cores4896279.5
ST962Stomach cancer with stomach tissue array, including pathology grade, TNM and clinical satge, 48 cases/96 cores, replacing STC9624896240.5
ST243Stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage, 2 serial sections, 24 cases/48 cores2448214.5
ST1501Stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage, 75 cases/150 cores75150279.5
ST1503Stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage, 75 cases/150 cores75150279.5
ST811Stomach cancer with stomach tissue array, including pathplogy grade, TNM and clinical stage, 80 cases/80 cores8080331.5
ST805Stomach disease spectrum (stomach cancer progression) tissue array, including pathology grade, 80 cases/80 cores8080292.5
ST1001b(ST1001a)Stomach disease spectrum (stomach cancer progression) tissue array, including pathology grade, TNM and clinical stage, 100 cases/100 cores, replacing ST1001a100100331.5
ST8019Stomach multiple benign lesion tissue array, 80 cases/80 cores8080331.5
SIN241aStomach tissue and duodenum tissue array, 24 cases/24 cores, replacing SIN2412424214.5
ST804Stomach adenocarcinoma and normal tissue array, including pathology grade, TNM and clinical satge, 40 cases/80 cores, no overlaps with BC01012 or ST8014080292.5
ST808Stomach adenocarcinoma and normal tissue array, including pathology grade, TNM and clinical satge, 80 cases/80 cores, replacing BS010328080292.5
BS01012dStomach adenocarcinoma tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores, replacing BS01012c7272182
BS01012Stomach adenocarcinoma tissue array, including pathology grade?72 cases /72 cores7272182
BS01011aStomach adenocarcinoma tissue array, including TNM, clinical stage and pathology grade, 72 cases/ 72 cores, replacing BS010117272292.5
ST991aStomach adenocarcinoma tissue microarray, including TNM, clinical stage and pathology grade, 33 cases/ 99cores, replacing ST9913399292.5
ST722Stomach adenocarcinoma with matched stomach tissue array, including pathology grade, TNM and clinical stage, 24 cases/72 cores2472331.5
STO501Stomach adenocarcinoma with stomach tissue array (2010 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 50 cases/50 cores5050175.5
STO502Multiple stomach cancer with matched adjacent normal tissue array (2010 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 25 cases/50 cores5050175.5
ST2161aMultiple stomach cancer with normal tissue array, including pathology grade, TNM and clinical stage, 216 cases/216 cores, replacing ST2161216216591.5

TMA Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH)

Notes:

1) TMA slides were sectioned and stored at 4°C and may not be fresh cut, but still suitable for IHC. Please request fresh cut if experiment involves phospho-specific antibodies, RNA studies, FISH or ISH, etc. A minimum of 3 slides per TMA must be purchased to cover the cost of trimming for fresh sectioning.
2) Most TMA slides were not coated with an extra layer of paraffin (tissue cores can be easily seen on the glass). To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60°C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.

TNM Grading

T – Primary tumor
      Tx – Primary tumor cannot be assessed
      T0 – No evidence of primary tumor
      Tis – Carcinoma in situ; intraepithelial or invasion of lamina propria
      T1 – Tumor invades submucosa
      T2 – Tumor invades muscularis propria
      T3 – Tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues.
      T4 – Tumor directly invades other organs or structures and/or perforate visceral peritoneum

N – Regional lymph nodes
     Nx – Regional lymph nodes cannot be assessed
     N0 – No regional lymph node metastasis
     N1 – Metastasis in 1 to 3 regional lymph nodes
     N2 – Metastasis in 4 or more regional lymph nodes

M – Distant metastasis
     Mx – Distant metastasis cannot be assessed
     M0 – No distant metastasis
     M1 – Distant metastasis

Stage of Cancer

  • Stage 0 means there’s no cancer, only abnormal cells with the potential to become cancer. This is also called carcinoma in situ.
  • Stage I means the cancer is small and only in one area. This is also called early-stage cancer.
  • Stage II and III mean the cancer is larger and has grown into nearby tissues or lymph nodes.
  • Stage IV means the cancer has spread to other parts of your body. It’s also called advanced or metastatic cancer.
Posted on

Soft Tissue Arrays

Please send your request for detailed information and quote to: info@vitrovivo.com

SKU#

DESCRIPTION

CASE

CORE

 PRICE ($)
SO301Pleomorphic liposarcoma tissue array, 30 cases/30 cores3030253.50
SO302Pleomorphic liposarcoma tissue array, including pathology grade, TNM and clinical stage, 30 cases/30 cores3030253.50
SO803Liparomphalus and liposarcoma tissue array, 80 cases/80 cores8080292.50
T243Soft tissue tumor and normal tissue test array, including TNM and clinical stage, 2 serial sections, 6 cases/24 cores122471.50
T242aSoft tissue tumor array with autopsy tissue as control, including TNM, clinical stage, 12 cases/ 24 cores, replacing T242122471.50
BC24011aSoft tissue tumor tissue array, including TNM, clinical stage and pathology grade, 63 cases/63 cores, replacing BC240116363292.50
SO482Soft tissue tumor tissue array, with normal tissue as control, including TNM and clinical stage, 48 cases/48 cores4848292.50
SO208bSoft tissue tumor with normal tissue array, 64 cases/192 cores,replacing SO208a64192591.50
SO8012Soft tissue tumor with normal tissue array, including TNM and clinical stage, 40 cases/80 cores4080292.50
SOF501Soft tumor tissue with normal tissue array, including TNM and clinical stage, 50 cases/50 core5050221.00
BC24007Soft tissue tumor disease spectrum (progression) tissue array, 80 cases/80 cores8080331.50
SSO-961(SO961)Soft tissue fibrosarcoma tissue array (2013 WHO classification), including TNM and clinical stage (AJCC 7th edition), 96 cases/96 cores9696331.50
T244aSoft tissue malignant tumor tissue array, including TNM and clinical stage, 6 cases/24 cores, replacing ST24462471.50
SO801bSoft tissue malignant tumor with adjacent tissue array, including TNM and clinical stage, 80 cases/80 cores, replacing SO801a8080331.50

TMA Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH)

Notes:

1) TMA slides were sectioned and stored at 4°C and may not be fresh cut, but still suitable for IHC. Please request fresh cut if experiment involves phospho-specific antibodies, RNA studies, FISH or ISH, etc. A minimum of 3 slides per TMA must be purchased to cover the cost of trimming for fresh sectioning.
2) Most TMA slides were not coated with an extra layer of paraffin (tissue cores can be easily seen on the glass). To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60°C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.

TNM Grading

T – Primary tumor
      Tx – Primary tumor cannot be assessed
      T0 – No evidence of primary tumor
      Tis – Carcinoma in situ; intraepithelial or invasion of lamina propria
      T1 – Tumor invades submucosa
      T2 – Tumor invades muscularis propria
      T3 – Tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues.
      T4 – Tumor directly invades other organs or structures and/or perforate visceral peritoneum

N – Regional lymph nodes
     Nx – Regional lymph nodes cannot be assessed
     N0 – No regional lymph node metastasis
     N1 – Metastasis in 1 to 3 regional lymph nodes
     N2 – Metastasis in 4 or more regional lymph nodes

M – Distant metastasis
     Mx – Distant metastasis cannot be assessed
     M0 – No distant metastasis
     M1 – Distant metastasis

Stage of Cancer

  • Stage 0 means there’s no cancer, only abnormal cells with the potential to become cancer. This is also called carcinoma in situ.
  • Stage I means the cancer is small and only in one area. This is also called early-stage cancer.
  • Stage II and III mean the cancer is larger and has grown into nearby tissues or lymph nodes.
  • Stage IV means the cancer has spread to other parts of your body. It’s also called advanced or metastatic cancer.
Posted on

Small Intestine Tissue Arrays

Please send your request for detailed information and quote to: info@vitrovivo.com

SKU#

DESCRIPTION

CASE

CORE

PRICE ($)

SM241Small intestine adenocarcinoma and adjacent normal tissue array, including pathology grade, 6 cases/24 cores62471.50
SM242Small intestine adenocarcinoma with small intestine tissue array, including pathology grade, 12 cases/24 cores121271.50
T421aSmall intestine cancer with normal tissue test array, including pathology grade, TNM and clinical stage and, 6 cases/24 cores, replacing T42162452.0
T423Small intestine cancer with small intestine test array, including pathology grade, TNM and clinical stage, 6 cases/24 cores62471.50

TMA Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH)

Notes:

1) TMA slides were sectioned and stored at 4°C and may not be fresh cut, but still suitable for IHC. Please request fresh cut if experiment involves phospho-specific antibodies, RNA studies, FISH or ISH, etc. A minimum of 3 slides per TMA must be purchased to cover the cost of trimming for fresh sectioning.
2) Most TMA slides were not coated with an extra layer of paraffin (tissue cores can be easily seen on the glass). To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60°C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.

TNM Grading

T – Primary tumor
      Tx – Primary tumor cannot be assessed
      T0 – No evidence of primary tumor
      Tis – Carcinoma in situ; intraepithelial or invasion of lamina propria
      T1 – Tumor invades submucosa
      T2 – Tumor invades muscularis propria
      T3 – Tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues.
      T4 – Tumor directly invades other organs or structures and/or perforate visceral peritoneum

N – Regional lymph nodes
     Nx – Regional lymph nodes cannot be assessed
     N0 – No regional lymph node metastasis
     N1 – Metastasis in 1 to 3 regional lymph nodes
     N2 – Metastasis in 4 or more regional lymph nodes

M – Distant metastasis
     Mx – Distant metastasis cannot be assessed
     M0 – No distant metastasis
     M1 – Distant metastasis

Stage of Cancer

  • Stage 0 means there’s no cancer, only abnormal cells with the potential to become cancer. This is also called carcinoma in situ.
  • Stage I means the cancer is small and only in one area. This is also called early-stage cancer.
  • Stage II and III mean the cancer is larger and has grown into nearby tissues or lymph nodes.
  • Stage IV means the cancer has spread to other parts of your body. It’s also called advanced or metastatic cancer.
Posted on

Skin Tissue Arrays

Please send your request for detailed information and quote to: info@vitrovivo.com

SKU#

DESCRIPTION

CASE

CORE

PRICE ($)

ME481bMelanoma tissue array with adjacent normal skin tissue, including TNM and clinical stage, 48 cases/48 cores, replaced by ME481c4848182.00
MEL501Multiple sites of malignant melanoma with skin tissue array (2018 WHO classification), including pathology grade, TNM and clinical satge (AJCC 7th edition), 50 cases/50 cores5050175.50
AC451Condyloma acuminatum and skin tissue array, 45 cases/45 cores4545214.50
SK244bAge grouped female skin tissue array, 12 cases/24 cores, replacing SK244a1224292.50
T388Malignant melanoma test tissue array, including TNM and clinical stage, 6 cases/24 cores62471.50
T388aMalignant melanoma test tissue array, including TNM and clinical stage, 6 cases/24 cores62471.50
ME1002aMalignant melanoma tissue array with normal skin tissue as control, including pathology grade, TNM and clinical stage, 50 cases/100 cores, replacing ME100250100377.00
TMA-120Malignant melanoma tissue array with skin tissue, 50 cases/100 cores50100331.50
ME483aMalignant melanoma tissue array, including TNM and clinical stage, 48 cases/48 cores, replacing ME4834848292.50
SK181aMalignant melanoma with benign nevus tissue array, including TNM and clinical stage, 18 cases/18 cores, replacing SK1811818188.50
T383bMalignant melanoma with normal skin tissue test array, including TNM and clinical stage, 6 cases/24 cores, replacing T383a62471.50
ME802Malignant melanoma with normal tissue array, 40 cases/80 cores4080331.50
ME242dMalignant melanoma with skin tissue array, including TNM and clinical stage, 24 cases/24 cores, replacing ME242c242471.50
ME481dMalignant melanoma with skin tissue array, including TNM and clinical stage, 48 cases/48 cores, replacing ME481c4848182.00
ME1002cMalignant melanoma with skin tissue array, including TNM and clinical stage, 50 cases/100 cores, replacing ME1002b50100377.00
T382bMalignant melanoma with skin tissue test array, including TNM and clinical stage, 12 cases/24 cores, replacing T382a122471.50
T382dMalignant melanoma with skin tissue test array, including TNM and clinical stage, 12 cases/24 cores, replacing T382c122471.50
MME1004iMalignant melanoma, metastatic malignant melanoma and nevus tissue array, including TNM and clinical stage, 100 cases/100 cores, replacing ME1004h100100383.50
MME981Malignant melanoma, metastatic malignant melanoma and nevus tissue array, including TNM and clinical stage, 98 cases/98 cores9898383.50
SK241aSkin cancer tissue array with adjacent normal skin tissue as control, including TNM, clinical stage and pathology grade, 12 cases/24 cores, replacing SK241122484.50
T211bSkin cancer tissue array with normal skin tissue, including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T211a62452.00
ME482bSkin malignant melanoma with skin tissue array, including TNM and clinical stage, 48 cases/ 48 cores, replacing ME482a4848292.50
SKI501Skin malignant tumor with skin tissue array (2018 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 50 cases/50 cores5050221.00
SKI503Skin squamous cell carcinoma with skin tissue array (2018 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 50 cases/50 cores5050221.00
SK961Skin tumor tissue array, including TNM, clinical stage and pathology grade, 48 cases/96 cores4896279.50
T214Skin tumor tissue array, including TNM, clinical stage and pathology grade, 6 cases/24 cores62471.50
T212aSkin tumor tissue array, with normal tissue as control, including TNM, clinical stage and pathology grade, 12 cases/24 cores, replacing T212122471.50
SKI-461Skin tumor with matched skin tissue array (2018 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 23 cases/46 cores2346221.00
SKI502Skin tumor with matched skin tissue array (2018 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 25 cases/50 cores5050221.00
SKI504Skin basal cell carcinoma with skin tissue array (2019 WHO classification), including pathology grade, TNM and clinical stage (AJCC 7th edition), 50 cases/50 cores5050221.00

TMA Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH)

Notes:

1) TMA slides were sectioned and stored at 4°C and may not be fresh cut, but still suitable for IHC. Please request fresh cut if experiment involves phospho-specific antibodies, RNA studies, FISH or ISH, etc. A minimum of 3 slides per TMA must be purchased to cover the cost of trimming for fresh sectioning.
2) Most TMA slides were not coated with an extra layer of paraffin (tissue cores can be easily seen on the glass). To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60°C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.

TNM Grading

T – Primary tumor
      Tx – Primary tumor cannot be assessed
      T0 – No evidence of primary tumor
      Tis – Carcinoma in situ; intraepithelial or invasion of lamina propria
      T1 – Tumor invades submucosa
      T2 – Tumor invades muscularis propria
      T3 – Tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues.
      T4 – Tumor directly invades other organs or structures and/or perforate visceral peritoneum

N – Regional lymph nodes
     Nx – Regional lymph nodes cannot be assessed
     N0 – No regional lymph node metastasis
     N1 – Metastasis in 1 to 3 regional lymph nodes
     N2 – Metastasis in 4 or more regional lymph nodes

M – Distant metastasis
     Mx – Distant metastasis cannot be assessed
     M0 – No distant metastasis
     M1 – Distant metastasis

Stage of Cancer

  • Stage 0 means there’s no cancer, only abnormal cells with the potential to become cancer. This is also called carcinoma in situ.
  • Stage I means the cancer is small and only in one area. This is also called early-stage cancer.
  • Stage II and III mean the cancer is larger and has grown into nearby tissues or lymph nodes.
  • Stage IV means the cancer has spread to other parts of your body. It’s also called advanced or metastatic cancer.
Posted on

Rectum Tissue Arrays

Please send your request for detailed information and quote to: info@vitrovivo.com

SKU#

DESCRIPTION

CASE

CORE

PRICE ($)

RE2001High-density (200 core) rectum cancer tissue array with matched adjacent normal tissue, 192 cases/208 cores192200448.50
T061Rectal cancer test tissue array, with normal rectal control tissues, including TNM, clinical stage and pathology grade, 6 cases/24 cores62445.50
RE242bRectum cancer and adjacent normal rectum tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing RE242a122471.50
RE722Rectum cancer tissue array with matched rectum tissue, including pathology grade, TNM and clinical stage, 24 cases/72 cores2472292.50
RE482Rectum cancer tissue array with normal tissue, including pathology grade, TNM and clinical stage, 48 cases/48 cores4848149.50
RE1021Rectum cancer tissue array, including pathology grade, TNM and clinical stage, 102 cases/102 cores102102331.50
REC502Rectum cancer with matched rectum tissue array (2010 WHO classification), including pathology grade, TNM and clinical satge (AJCC 7th edition), 25 cases/50 cores5050175.50
RE1505Rectum cancer with matched rectum tissue array, including pathology grade, TNM and clinical stage, 50 cases/150 cores50150279.50
RE242Rectum cancer with rectum tissue test array, including pathology grade, TNM and clinical stage, 2 serial sections, 6 cases/24 cores122471.50
T063Rectum cancer with rectum tissue test array, including pathology grade, TNM and clinical stage, 2 serial sections, 6 cases/24 cores62445.50
RE2081Rectum disease spectrum tissue array, including pathology grade, 98 cases/208 cores98208591.50
RE721Normal rectum and cancer tissue array, including pathology grade, 22 cases/72 cores2272292.50
RE802Normal rectum and cancer tissue array, including pathology grade, 74 cases/80 cores7480292.50
RE723Rectum adenocarcinoma (grade 2) tissue array with adjacent normal tissue, including pathology grade, TNM and clinical stage, 24 cases/72 cores2472292.50
RE724Rectum adenocarcinoma (grade 3) tissue array with normal tissue, including pathology grade, TNM and clinical stage, 24 cases/72 cores2472292.50
RE803Rectum adenocarcinoma tissue array with adjacent normal tissue, including pathology grade, TNM and clinical stage, 73 cases/80 cores7480292.50
RE2161Rectum adenocarcinoma tissue array, including pathology grade, TNM and clinical stage, 216 cases/216 cores216216591.50
RE961Rectum adenocarcinoma tissue array, including pathology grade, TNM and clinical stage, 48 cases/96 cores4896279.50
RE962Rectum adenocarcinoma tissue array, including pathology grade, TNM and clinical stage, 48 cases/96 cores4896279.50
REC501Rectum adenocarcinoma with rectum tissue array (2010 WHO classification), including pathology grade, TNM and clinical satge (AJCC 7th edition), 50 cases/50 cores5050175.50
RE1502Rectum adenocarcinoma with rectum tissue array, including pathology grade, TNM and clinical stage, 75 cases/150 cores75150279.50

TMA Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH)

Notes:

1) TMA slides were sectioned and stored at 4°C and may not be fresh cut, but still suitable for IHC. Please request fresh cut if experiment involves phospho-specific antibodies, RNA studies, FISH or ISH, etc. A minimum of 3 slides per TMA must be purchased to cover the cost of trimming for fresh sectioning.
2) Most TMA slides were not coated with an extra layer of paraffin (tissue cores can be easily seen on the glass). To prevent tissue detachment during antigen retrieval, unbaked slides must be baked for at least 30 to 120 minutes at 60°C. before putting into xylene for de-paraffinization. Baked slides were sent out baked for 2 hours.

TNM Grading

T – Primary tumor
      Tx – Primary tumor cannot be assessed
      T0 – No evidence of primary tumor
      Tis – Carcinoma in situ; intraepithelial or invasion of lamina propria
      T1 – Tumor invades submucosa
      T2 – Tumor invades muscularis propria
      T3 – Tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues.
      T4 – Tumor directly invades other organs or structures and/or perforate visceral peritoneum

N – Regional lymph nodes
     Nx – Regional lymph nodes cannot be assessed
     N0 – No regional lymph node metastasis
     N1 – Metastasis in 1 to 3 regional lymph nodes
     N2 – Metastasis in 4 or more regional lymph nodes

M – Distant metastasis
     Mx – Distant metastasis cannot be assessed
     M0 – No distant metastasis
     M1 – Distant metastasis

Stage of Cancer

  • Stage 0 means there’s no cancer, only abnormal cells with the potential to become cancer. This is also called carcinoma in situ.
  • Stage I means the cancer is small and only in one area. This is also called early-stage cancer.
  • Stage II and III mean the cancer is larger and has grown into nearby tissues or lymph nodes.
  • Stage IV means the cancer has spread to other parts of your body. It’s also called advanced or metastatic cancer.