Biospecimen

Customized Biospecimen Collection for Biomedical Research

VitroVivo Biotechis a leading Contract Research Organisation (CRO) company which offers biospecimen collection services to meet biomedical scientist’s needs of their research project. As our team members are experienced senior PhD level molecular pathology scientists and certified pathologists, we are able to take measures for extraordinary sample quality control and provide biospecimens with the highest quality.  We work closely with clients on their study design to achieve the specific objectives set for the research projects. In addition, we are positioned to perform full-scale histopathology services and other molecular biological experiments on-site. We are a professional hisopathology company you can trust for customized biospecimen collection services. 

Customized Biospecimen Collection

Pure Cell Population Dissected by LCM

We provide support and services in

  • Biospecimen Collection protocol development
  • IRB submission
  • Informed consent form customization
  • Sample collection, processing and transportation
  • Case report form implementation
  • Sample storage under desired environment

Our clinical site for biospecimen collection is closely monitored and managed by site coordinators whose responsibilities include regular personnel training, sample collection oversight,  inventory supplies and specimen logistics.

Service  Categories

Description of Customized Biospecimen Collection Services

 Specimen Combinations Specimens can be supplied either as individual samples or as different specimen combinations to meet various research purposes.
 Matched Specimen Set — Same Donor Based
  • Fresh frozen tumor and adjacent normal tissue 
  • Fresh frozen tumor and FFPE tumor tissue block 
  • Fresh frozen or FFPE tumor tissue specimens and metastatic samples 
  • Matching fresh frozen tissue set and FFPE tumor/adjacent normal tissue set 
  • FFPE tumor and adjacent normal tissue block 
  • Fresh frozen or FFPE tissue samples with biofluids collected
 Retrospective/Archival Samples FFPE blocks collected and stored at major clinical sites and our repository. Treatment information and clinical outcome can be provided for up to 10 years from the date of collection. Matching recurrent /metastatic tumor FFPE block can be provided upon request.
Prospective Sample Collection Fresh frozen tissues, FFPE blocks, matching biofluids and other specimen formats can be procured according to Capital Bio-sciences standard collection protocols or custom developed protocols. Treatment and follow-up information can be provided for majority of prospectively collected samples.
FFPE Blocks and Slides
  • Tumor tissues and other disease samples
  • Normal tissues

Formalin Fixed Paraffin Embedded (FFPE) tissue block is prepared by tissue fixed in 10% neutral-buffered formalin and embedded in IHC-grade paraffin wax. Standard tissue size is 1×1×0.5 cm, but it can vary depending on the nature of the disease and tissue type. The fixation agent and the embedding media could be customized if requested. FFPE blocks are collected under VitroVivo Standard Operating Procedures (SOPs).

Fresh Frozen Tissue and Slides
  • Tumor tissues and other disease samples
  • Normal tissues

Fresh frozen tissue samples collected by certified medical pathologists are snap-frozen in liquid nitrogen within 30 minutes of surgical excision. Sample can be collected into OCT embedding media upon request. Standard sample weight is 0.5 – 1 gram. Fresh frozen tissue samples are collected under VitroViVo Standard Operating Procedures (SOPs)

Biofluids
  • Normal tissues
  • Tumor tissues and other disease samples

VitroVivo Biotech provides various biological fluids under standard collection protocols or with modified protocols if it is for custom procurement projects.

Blood   VitroVivo Biotech can supply up to 15 ml of whole blood from one donor. Standard Blood samples are collected into 4-8 ml K2 EDTA tube (anti-coagulation agent can be changed upon request). 
Bone Marrow  Bone Marrow is from patients with hematological malignancies. Standard sample is collected as 0.5-1 ml snap-frozen aspirate. Bone marrow smear on a glass microscopic slide can be provided upon request.
Other Biofluids  Serum, Plasma, Urine, Saliva, Synovial and Cerebrospinal Fluid
Cell Fractions
  • Subcellular fractions from whole blood and bone marrow aspirate can be prepared upon request.
  • Peripheral blood mononuclear cells (PBMC) can be supplied as viable and snap-frozen samples. 
  • Bone marrow mononuclear cells (BMMC) can be prepared as viable and frozen samples.
  • Cell fraction samples are collected into standard cryovials under VitroVivo Biotech 
  • RNA and DNA (available upon request)
  • Primary Cell Lines and viable tumor pieces (available upon request)
  • Fresh Biospecimens Collection (available upon request)
Pure cells dissected by LCM VitroVivo provides some customized pure cell population which are microdissected by ArcturusXT™ LCM system.


Inquiries and Orders

Please fill out the Customized Biospecimen Collection Service Request Form below and enter as much detail as possible. VitroVivo will conduct a quick feasibility study and get back to you with information on availability, time duration and pricing within 24 hours.