Human Breast Cancer FFPE Sections

Human breast cancer is a complex and heterogeneous disease that can be classified into different molecular types based on specific molecular markers. The most commonly used classification system involves categorizing breast cancer into the following molecular subtypes:

Table Characteristics of subtypes of breast cancer (Reference: https://www.ncbi.nlm.nih.gov/books/NBK583808/)

	Luminal A (ER+/PR+/HER2-)	Luminal B(ER+/PR+/HER2-BRCA2+)	HER2(ER+/PR+/HER2+)	TNBC(ER-/PR-/HER2-)
Frequency (%)	50	15	20	15
ER	Yes	Yes	Some cases	No
PR	Yes	Some cases	Some cases	No
HER	No	No	Yes	No
miRNAs	Let-7f, Let-7c, miR-10, miR-29a, miR-181a, miR-223 and miR-652	miR155, miR-93, miR-18a, miR-135b, miR-718, miR-4516, miR-210, and miR-125b-5p	miR-150 and miR-142–3p	miR-153, miR-10b, miR-26a, and miR146a
Ki67	Some cases	Some cases	High	High
Mutations	No	BRCA2	p53	p53 and BRCA1
Prognosis	Good	Middle	Middle/Bad	Bad
Therapy	Hormonal	Hormonal/ Chemo	Hormonal/Chemo/ Herceptin	Chemo/ Experimental

ER, estrogen receptor; HER, human epidermal receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor; TNBC, triple-negative breast cancer.

VitroVivo Biotech provide  human breast cancer FFPE sections with ER,PR and HER2 data. These sections are mounted on positively charged glass slides and sectioned at 5 µm thickness. These FFPE slides can be used to perform RNA scope ISH, FISH IF, IHC and NGS, etc.