Human Breast Cancer FFPE Sections

Human breast cancer is a complex and heterogeneous disease that can be classified into different molecular types based on specific molecular markers. The most commonly used classification system involves categorizing breast cancer into the following molecular subtypes:

Table Characteristics of subtypes of breast cancer (Reference:

Luminal A (ER+/PR+/HER2-) Luminal B(ER+/PR+/HER2-BRCA2+) HER2(ER+/PR+/HER2+) TNBC(ER-/PR-/HER2-)
Frequency (%) 50 15 20 15
ER Yes Yes Some cases No
PR Yes Some cases Some cases No
HER No No Yes No
miRNAs Let-7f, Let-7c, miR-10miR-29a, miR-181amiR-223 and miR-652 miR155, miR-93, miR-18a, miR-135b, miR-718, miR-4516, miR-210, and miR-125b-5p miR-150 and miR-142–3p miR-153, miR-10b, miR-26a, and miR146a
Ki67 Some cases Some cases High High
Mutations No BRCA2 p53 p53 and BRCA1
Prognosis Good Middle Middle/Bad Bad
Therapy Hormonal Hormonal/ Chemo Hormonal/Chemo/ Herceptin Chemo/ Experimental

ER, estrogen receptor; HER, human epidermal receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor; TNBC, triple-negative breast cancer.

VitroVivo Biotech provide  human breast cancer FFPE sections with ER,PR and HER2 data. These sections are mounted on positively charged glass slides and sectioned at 5 µm thickness. These FFPE slides can be used to perform RNA scope ISH, FISH IF, IHC and NGS, etc.